Rb Polyclonal Antibody, 50ul[BT-AP07690] Nucleic Acid Extraction MAPKKK5 contains 1|374 amino acids

MAPKKK5 contains 1|374 amino acids with all 11 kinase subdomains

including the BRCA1-A complex and the BRISC complex

tissue specificity:B-cell specific

TIM family

the protein was only detected in CD34+ progenitor cells present in blood and in CD31+ endothelial cells surrounding the blood vessels

Rb Polyclonal Antibody, 50ul[BT-AP07690] Nucleic Acid Extraction MAPKKK5 contains 1|374 amino acidsThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.