Ref-1 Polyclonal Antibody, 100ul[BT-AP07734] Modified Oligos Mutations in this gene contribute

Mutations in this gene contribute to mitochondrial complex 1 deficiency

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin

Important for the resorption of phosphate by the kidney

The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene

as represented in GeneID: 106780802

Ref-1 Polyclonal Antibody, 100ul[BT-AP07734] Modified Oligos Mutations in this gene contributeApurinic apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. APEX1 encodes the major AP endonuclease in human cells.