CO2 Polyclonal Antibody, 20ul Modification Enzymes The encoded protein (B-cell receptor-associated

The encoded protein (B-cell receptor-associated protein 31) is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis

Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14

The cleavage does not take place when the receptor is associated with netrin ligand

Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus

Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly

CO2 Polyclonal Antibody, 20ul Modification Enzymes The encoded protein (B-cell receptor-associatedComponent C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age related macular degeneration. This gene